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KMID : 1189420060190010123
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2006 Volume.19 No. 1 p.123 ~ p.134
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The Experimental Study on Anti-bacterial Potency of Variou Herb-medicine used for eye disease on Staphylococcus epidermidis Keratitis
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Jung Soon-Young
Seo Hyeong-Sik
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Abstract
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Objective: This experimental study was performed to investigate the effect of Herbe-medicine used for eye disease(Sean-tang, Jinpi-san, Tangpo-san, Copitdis Rhizoma) on Staphylococcus epidermidis keratitis.
Methods: After administering various herbal eye drops on Staphylococcus epidermidis, I measured MIC and the size of inhibition zone. MIC was measured by dropping from 20 to 50ul according to density. Anti-bacterial potency was measured by the size of inhibition zone with change of volume under 2 days culture condition. Also continuous anti-bacterial potency of herbal eye drops was measured by the size of inhibition zone according to 2 days and 6 days culture each under the 50ul condition.
Results: 1. MIC on Staphylococcus epidermidis in Sean-tang, Jinpi-san was 1%, 50ul 2. MIC on Staphylococcus epidermidis in Tangpo-san, Coptidis rhizoma was 10%, 50ul 3. MIC on Staphylococcus epidermidis in Cravit was 0.1%, 50ul. 4. Under the 2 days culture condition, the size of inhibition zone on Staphylococcus epidermidis by volume for Sean-tang was 10.0mm in 50ul, Jinpi-san was 16.0mm in 50ul, Tangpo-san was 17.5mm in 50ul, Coptidis rhizoma was 31.0mm in 50ul and Cravit was 34mm in 50ul, showed the highest anti-bacterial potency. 5. Under the 50ul condition, the size of inhibition zone on Staphylococcus epidermidis by 2 and 6 culture days for Sean-tang was 47.5mm in 6days, Jinpi-san was 36.0mm in 6days, Tangpo-san was 45.0mm in 6 days and Cravit was 48.0mm in 6 days, which showed the highest anti-bacterial potency. 6. Under the 50ul culture condition, the size of inhibition zone on Staphylococcus epidermidis by 2 and 6 culture days for Coptidis rhizoma was 31.0mm in 2 days and 6 days, which showed the same anti-bacteria1 potency.
Conclusions: The present author think that Herbe-medicine used for eye disease can be used to cure Staphylococcus epidermidis keratitis and if further study is performed, the use of the Herbe-medicine used for eye disease will be valuable and beneficial in the clinical medicines.
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KEYWORD
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Staphylococcusepidermidiskeratitis, Herbe-medicineusedforeyedisease(Sean-tang, Jinpi-san, Tangpo-san, CopitdisRhizoma), MIC, Inhibitionzone, Growthinhibitioneffect
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